3ffn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:49, 21 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ffn.png|left|200px]]
 
-
{{STRUCTURE_3ffn| PDB=3ffn | SCENE= }}
+
==Crystal structure of calcium-free human gelsolin==
-
 
+
<StructureSection load='3ffn' size='340' side='right'caption='[[3ffn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
===Crystal structure of calcium-free human gelsolin===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3ffn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFN FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_19666512}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffn OCA], [https://pdbe.org/3ffn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffn RCSB], [https://www.ebi.ac.uk/pdbsum/3ffn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffn ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[3ffn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFN OCA].
+
== Disease ==
 +
[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[https://omim.org/entry/105120 105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ffn ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Gelsolin|Gelsolin]]
+
*[[Gelsolin 3D structures|Gelsolin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:019666512</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Burtnick, L D.]]
+
[[Category: Large Structures]]
-
[[Category: Chumnarnsilpa, S.]]
+
[[Category: Burtnick LD]]
-
[[Category: Robinson, R C.]]
+
[[Category: Chumnarnsilpa S]]
-
[[Category: Actin]]
+
[[Category: Robinson RC]]
-
[[Category: Actin binding protein]]
+
-
[[Category: Actin capping]]
+
-
[[Category: Actin-binding]]
+
-
[[Category: Alternative initiation]]
+
-
[[Category: Amyloid]]
+
-
[[Category: Amyloidosis]]
+
-
[[Category: Ca-dependent]]
+
-
[[Category: Cytoskeleton]]
+
-
[[Category: Disease mutation]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Gelsolin]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Secreted]]
+

Current revision

Crystal structure of calcium-free human gelsolin

PDB ID 3ffn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ffn"
Personal tools