3mz4

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[[Image:3mz4.png|left|200px]]
 
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{{STRUCTURE_3mz4| PDB=3mz4 | SCENE= }}
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==Crystal structure of D101L Mn2+ HDAC8 complexed with M344==
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<StructureSection load='3mz4' size='340' side='right'caption='[[3mz4]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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===Crystal structure of D101L Mn2+ HDAC8 complexed with M344===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MZ4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20545365}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.845&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3N:4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE'>B3N</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mz4 OCA], [https://pdbe.org/3mz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3mz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mz4 ProSAT]</span></td></tr>
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[[3mz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZ4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/3mz4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mz4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Histone deacetylase|Histone deacetylase]]
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020545365</ref><references group="xtra"/>
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__TOC__
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[[Category: Histone deacetylase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Christianson, D W.]]
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[[Category: Large Structures]]
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[[Category: Dowling, D P.]]
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[[Category: Christianson DW]]
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[[Category: Fierke, C A.]]
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[[Category: Dowling DP]]
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[[Category: Gattis, S G.]]
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[[Category: Fierke CA]]
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[[Category: Arginase-like]]
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[[Category: Gattis SG]]
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[[Category: Hydrolase]]
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[[Category: Metallohydrolase]]
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Current revision

Crystal structure of D101L Mn2+ HDAC8 complexed with M344

PDB ID 3mz4

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