1zp7

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[[Image:1zp7.png|left|200px]]
 
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{{STRUCTURE_1zp7| PDB=1zp7 | SCENE= }}
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==The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.==
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<StructureSection load='1zp7' size='340' side='right'caption='[[1zp7]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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===The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zp7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZP7 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16154091}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zp7 OCA], [https://pdbe.org/1zp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zp7 RCSB], [https://www.ebi.ac.uk/pdbsum/1zp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zp7 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1zp7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP7 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/RECU_BACSU RECU_BACSU] Has at least 2 separable functions; Holliday junction resolution with generation of monomeric chromosomes, and modulation of RecA activity. Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. Partially inhibits the hydrolysis of dATP or rATP by RecA. Holliday junction resolution is stimulated by RuvB.<ref>PMID:14701911</ref> <ref>PMID:16020779</ref> <ref>PMID:16154091</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/1zp7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zp7 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Resolvase|Resolvase]]
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*[[Resolvase 3D structures|Resolvase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016154091</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Alonso, J C.]]
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[[Category: Large Structures]]
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[[Category: Ayora, S.]]
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[[Category: Alonso JC]]
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[[Category: Carrasco, B.]]
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[[Category: Ayora S]]
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[[Category: McGregor, N.]]
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[[Category: Carrasco B]]
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[[Category: Rafferty, J.]]
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[[Category: McGregor N]]
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[[Category: Sedelnikova, S.]]
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[[Category: Rafferty J]]
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[[Category: Thaw, P.]]
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[[Category: Sedelnikova S]]
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[[Category: Dna binding protein]]
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[[Category: Thaw P]]
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[[Category: Dna-binding protein]]
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[[Category: Recombination]]
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[[Category: Resolvase]]
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Current revision

The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.

PDB ID 1zp7

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