1zyx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:14, 15 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1zyx.png|left|200px]]
 
-
{{STRUCTURE_1zyx| PDB=1zyx | SCENE= }}
+
==Crystal structure of the complex of a group IIA phospholipase A2 with a synthetic anti-inflammatory agent licofelone at 1.9A resolution==
-
 
+
<StructureSection load='1zyx' size='340' side='right'caption='[[1zyx]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-
===Crystal structure of the complex of a group IIA phospholipase A2 with a synthetic anti-inflammatory agent licofelone at 1.9A resolution===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1zyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYX FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LCF:[6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC+ACID'>LCF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[1zyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYX OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyx OCA], [https://pdbe.org/1zyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyx RCSB], [https://www.ebi.ac.uk/pdbsum/1zyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyx ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyx_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zyx ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Phospholipase A2|Phospholipase A2]]
+
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
-
[[Category: Daboia russellii pulchella]]
+
== References ==
-
[[Category: Bhushan, A.]]
+
<references/>
-
[[Category: Jabeen, T.]]
+
__TOC__
-
[[Category: Sharma, S.]]
+
</StructureSection>
-
[[Category: Singh, N.]]
+
[[Category: Daboia russelii pulchella]]
-
[[Category: Singh, T P.]]
+
[[Category: Large Structures]]
-
[[Category: Complex]]
+
[[Category: Bhushan A]]
-
[[Category: Drug]]
+
[[Category: Jabeen T]]
-
[[Category: Hydrolase]]
+
[[Category: Sharma S]]
-
[[Category: Inhibitor]]
+
[[Category: Singh N]]
 +
[[Category: Singh TP]]

Current revision

Crystal structure of the complex of a group IIA phospholipase A2 with a synthetic anti-inflammatory agent licofelone at 1.9A resolution

PDB ID 1zyx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zyx"
Personal tools