3myo

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[[Image:3myo.png|left|200px]]
 
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{{STRUCTURE_3myo| PDB=3myo | SCENE= }}
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==Crystal structure of tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes==
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<StructureSection load='3myo' size='340' side='right'caption='[[3myo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3myo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MYO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3myo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3myo OCA], [https://pdbe.org/3myo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3myo RCSB], [https://www.ebi.ac.uk/pdbsum/3myo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3myo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LACD1_STRP1 LACD1_STRP1]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Staphylococcus aureus LacD, a Class I tagatose-1,6-bisphosphate (TBP) aldolase, shows broadened substrate specificity by catalyzing the cleavage of 1,6-bisphosphate derivatives of d-tagatose, d-fructose, d-sorbose, and d-psicose. LacD.1 and LacD.2 are two closely-related Class I TBP aldolases in Streptococcus pyogenes. Here we have determined the crystal structures of S. aureus LacD and S. pyogenes LacD.1. Monomers of both enzymes are folded into a (beta/alpha)(8) barrel and two monomers associate tightly to form a dimer in the crystals. The structures suggest that the residues E189 and S300 of rabbit muscle Class I fructose-1,6-bisphosphate (FBP) aldolase are important for substrate specificity. When we mutated the corresponding residues of S. aureus LacD, the mutants (L165E, L275S, and L165E/L275S) showed enhanced substrate specificity toward FBP. STRUCTURED SUMMARY: lacDbinds to lacD by X-ray crystallography(View interaction) lacD1binds to lacD1 by X-ray crystallography(View interaction).
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===Crystal structure of tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes===
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Crystal structures of LacD from Staphylococcus aureus and LacD.1 from Streptococcus pyogenes: Insights into substrate specificity and virulence gene regulation.,Lee SJ, Kim HS, Kim do J, Yoon HJ, Kim KH, Yoon JY, Suh SW FEBS Lett. 2011 Jan 21;585(2):307-12. Epub 2010 Dec 28. PMID:21192932<ref>PMID:21192932</ref>
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{{ABSTRACT_PUBMED_21192932}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3myo" style="background-color:#fffaf0;"></div>
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[[3myo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYO OCA].
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==See Also==
==See Also==
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*[[Aldolase|Aldolase]]
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021192932</ref><references group="xtra"/>
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__TOC__
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[[Category: Streptococcus pyogenes]]
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</StructureSection>
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[[Category: Tagatose-bisphosphate aldolase]]
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[[Category: Large Structures]]
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[[Category: Kim, D J.]]
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[[Category: Streptococcus pyogenes serotype M1]]
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[[Category: Kim, H S.]]
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[[Category: Kim DJ]]
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[[Category: Kim, K H.]]
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[[Category: Kim HS]]
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[[Category: Lee, S J.]]
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[[Category: Kim KH]]
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[[Category: Suh, S W.]]
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[[Category: Lee SJ]]
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[[Category: Yoon, H J.]]
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[[Category: Suh SW]]
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[[Category: Yoon, J Y.]]
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[[Category: Yoon HJ]]
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[[Category: Beta-alpha-barrel]]
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[[Category: Yoon JY]]
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[[Category: Lyase]]
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Current revision

Crystal structure of tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes

PDB ID 3myo

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