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1q5p

From Proteopedia

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[[Image:1q5p.png|left|200px]]
 
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{{STRUCTURE_1q5p| PDB=1q5p | SCENE= }}
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==S156E/S166D variant of Bacillus lentus subtilisin==
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<StructureSection load='1q5p' size='340' side='right'caption='[[1q5p]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===S156E/S166D variant of Bacillus lentus subtilisin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lederbergia_lenta Lederbergia lenta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q5P FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12962477}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SEB:O-BENZYLSULFONYL-SERINE'>SEB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5p OCA], [https://pdbe.org/1q5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q5p RCSB], [https://www.ebi.ac.uk/pdbsum/1q5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q5p ProSAT]</span></td></tr>
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[[1q5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5P OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SUBS_LEDLE SUBS_LEDLE] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/1q5p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q5p ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Subtilisin|Subtilisin]]
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*[[Subtilisin 3D structures|Subtilisin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012962477</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Bacillus lentus]]
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[[Category: Lederbergia lenta]]
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[[Category: Subtilisin]]
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[[Category: Bott RR]]
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[[Category: Bott, R R.]]
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[[Category: Chan G]]
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[[Category: Chan, G.]]
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[[Category: Domingo B]]
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[[Category: Domingo, B.]]
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[[Category: Ganshaw G]]
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[[Category: Ganshaw, G.]]
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[[Category: Hsia CY]]
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[[Category: Hsia, C Y.]]
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[[Category: Knapp M]]
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[[Category: Knapp, M.]]
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[[Category: Murray CJ]]
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[[Category: Murray, C J.]]
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[[Category: Altered flexibility]]
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[[Category: Hydrolase]]
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[[Category: Serine protease]]
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[[Category: Site-specific variant]]
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[[Category: Subtilisin]]
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Current revision

S156E/S166D variant of Bacillus lentus subtilisin

PDB ID 1q5p

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