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1mpl

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[[Image:1mpl.png|left|200px]]
 
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{{STRUCTURE_1mpl| PDB=1mpl | SCENE= }}
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==CRYSTAL STRUCTURE OF PHOSPHONATE-INHIBITED D-ALA-D-ALA PEPTIDASE REVEALS AN ANALOG OF A TETRAHEDRAL TRANSITION STATE==
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<StructureSection load='1mpl' size='340' side='right'caption='[[1mpl]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF PHOSPHONATE-INHIBITED D-ALA-D-ALA PEPTIDASE REVEALS AN ANALOG OF A TETRAHEDRAL TRANSITION STATE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mpl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._R61 Streptomyces sp. R61]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12564922}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.12&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=RE1:GLYCYL-L-A-AMINOPIMELYL-E-(D-2-AMINOETHYL)PHOSPHONATE'>RE1</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpl OCA], [https://pdbe.org/1mpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpl RCSB], [https://www.ebi.ac.uk/pdbsum/1mpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpl ProSAT]</span></td></tr>
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[[1mpl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DAC_STRSR DAC_STRSR] Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e. a D-alanyl-D-alanine-terminated peptide), it becomes immobilized in the form of a long-lived, serine-ester-linked acyl enzyme and thus behave as penicillin-binding protein (PBP).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/1mpl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mpl ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Carboxypeptidase|Carboxypeptidase]]
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
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*[[Penicillin-binding protein|Penicillin-binding protein]]
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:012564922</ref><references group="xtra"/>
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[[Category: Streptomyces sp. R61]]
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[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
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[[Category: Anderson JW]]
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[[Category: Streptomyces sp.]]
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[[Category: Brinsmade SR]]
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[[Category: Anderson, J W.]]
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[[Category: Kelly JA]]
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[[Category: Brinsmade, S R.]]
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[[Category: Pratt RF]]
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[[Category: Kelly, J A.]]
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[[Category: Silvaggi NR]]
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[[Category: Pratt, R F.]]
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[[Category: Silvaggi, N R.]]
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[[Category: Hydrolase]]
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[[Category: Penicillin binding protein]]
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[[Category: Peptidoglycan]]
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[[Category: Transition state analog]]
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Current revision

CRYSTAL STRUCTURE OF PHOSPHONATE-INHIBITED D-ALA-D-ALA PEPTIDASE REVEALS AN ANALOG OF A TETRAHEDRAL TRANSITION STATE

PDB ID 1mpl

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