1q3a

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[[Image:1q3a.png|left|200px]]
 
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{{STRUCTURE_1q3a| PDB=1q3a | SCENE= }}
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==Crystal structure of the catalytic domain of human matrix metalloproteinase 10==
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<StructureSection load='1q3a' size='340' side='right'caption='[[1q3a]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q3a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3a OCA], [https://pdbe.org/1q3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3a RCSB], [https://www.ebi.ac.uk/pdbsum/1q3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP10_HUMAN MMP10_HUMAN] Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q3a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The catalytic domain of matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 A resolution. The availability of this structure allowed us to critically examine the small differences existing between the catalytic domains of MMP-3 and MMP-10, which show the highest sequence identity among all MMPs. Furthermore, the binding mode of N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH), which is one of the most known commercial inhibitors of MMPs, is described for the first time.
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===Crystal structure of the catalytic domain of human matrix metalloproteinase 10===
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Crystal structure of the catalytic domain of human matrix metalloproteinase 10.,Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B J Mol Biol. 2004 Feb 20;336(3):707-16. PMID:15095982<ref>PMID:15095982</ref>
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{{ABSTRACT_PUBMED_15095982}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1q3a" style="background-color:#fffaf0;"></div>
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[[1q3a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3A OCA].
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==See Also==
==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015095982</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Stromelysin 2]]
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[[Category: Large Structures]]
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[[Category: Bertini, I.]]
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[[Category: Bertini I]]
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[[Category: Calderone, V.]]
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[[Category: Calderone V]]
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[[Category: Fragai, M.]]
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[[Category: Fragai M]]
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[[Category: Luchinat, C.]]
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[[Category: Luchinat C]]
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[[Category: Mangani, S.]]
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[[Category: Mangani S]]
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[[Category: Terni, B.]]
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[[Category: Terni B]]
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[[Category: Hydrolase]]
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[[Category: Hydroxamic acid]]
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[[Category: Inhibitor]]
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[[Category: Metalloproteinase]]
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[[Category: Mmp-10]]
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[[Category: Nngh]]
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[[Category: Stromelysin-2]]
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Current revision

Crystal structure of the catalytic domain of human matrix metalloproteinase 10

PDB ID 1q3a

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