2ktd
From Proteopedia
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| - | [[Image:2ktd.png|left|200px]] | ||
| - | + | ==Solution structure of mouse lipocalin-type prostaglandin D synthase / substrate analog (U-46619) complex== | |
| - | + | <StructureSection load='2ktd' size='340' side='right'caption='[[2ktd]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2ktd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KTD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PUC:(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-5-YL}HEPT-5-ENOIC+ACID'>PUC</scene></td></tr> |
| - | [[2ktd]] is a 1 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ktd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktd OCA], [https://pdbe.org/2ktd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ktd RCSB], [https://www.ebi.ac.uk/pdbsum/2ktd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktd ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTGDS_MOUSE PTGDS_MOUSE] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:8922532</ref> <ref>PMID:9892701</ref> <ref>PMID:10781097</ref> <ref>PMID:11751991</ref> <ref>PMID:12077186</ref> <ref>PMID:17715133</ref> <ref>PMID:19546224</ref> <ref>PMID:19833210</ref> | ||
==See Also== | ==See Also== | ||
*[[Prostaglandin D synthase|Prostaglandin D synthase]] | *[[Prostaglandin D synthase|Prostaglandin D synthase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Kato N]] | |
| - | [[Category: Kato | + | [[Category: Maruo H]] |
| - | [[Category: Maruo | + | [[Category: Ohkubo T]] |
| - | [[Category: Ohkubo | + | [[Category: Shimamoto S]] |
| - | [[Category: Shimamoto | + | [[Category: Yoshida T]] |
| - | [[Category: Yoshida | + | |
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Current revision
Solution structure of mouse lipocalin-type prostaglandin D synthase / substrate analog (U-46619) complex
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Categories: Large Structures | Mus musculus | Kato N | Maruo H | Ohkubo T | Shimamoto S | Yoshida T
