2aiv

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[[Image:2aiv.png|left|200px]]
 
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{{STRUCTURE_2aiv| PDB=2aiv | SCENE= }}
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==Multiple conformations in the ligand-binding site of the yeast nuclear pore targeting domain of NUP116P==
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<StructureSection load='2aiv' size='340' side='right'caption='[[2aiv]]' scene=''>
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===Multiple conformations in the ligand-binding site of the yeast nuclear pore targeting domain of NUP116P===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2aiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AIV FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16105837}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aiv OCA], [https://pdbe.org/2aiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aiv RCSB], [https://www.ebi.ac.uk/pdbsum/2aiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aiv ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2aiv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIV OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/NU116_YEAST NU116_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP116 plays an important role in several nuclear export and import pathways including poly(A)+ RNA, tRNA, pre-ribosome, and protein transport.<ref>PMID:8044840</ref> <ref>PMID:8524308</ref> <ref>PMID:9463388</ref> <ref>PMID:9891088</ref> <ref>PMID:10891509</ref> <ref>PMID:10952996</ref> <ref>PMID:11071906</ref> <ref>PMID:10801828</ref> <ref>PMID:11387327</ref> <ref>PMID:11689687</ref> <ref>PMID:11104765</ref> <ref>PMID:12372823</ref> <ref>PMID:12604785</ref> <ref>PMID:15039779</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2aiv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aiv ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoporin|Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016105837</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Hogle, J.]]
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[[Category: Hogle J]]
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[[Category: Park, S.]]
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[[Category: Park S]]
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[[Category: Robinson, M A.]]
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[[Category: Robinson MA]]
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[[Category: Silver, P.]]
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[[Category: Silver P]]
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[[Category: Sun, Z-Y J.]]
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[[Category: Sun Z-YJ]]
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[[Category: Wagner, G.]]
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[[Category: Wagner G]]
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[[Category: Beta sandwich]]
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[[Category: Transport protein]]
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Current revision

Multiple conformations in the ligand-binding site of the yeast nuclear pore targeting domain of NUP116P

PDB ID 2aiv

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