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1lwu

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[[Image:1lwu.png|left|200px]]
 
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{{STRUCTURE_1lwu| PDB=1lwu | SCENE= }}
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==Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide==
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<StructureSection load='1lwu' size='340' side='right'caption='[[1lwu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lwu]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LWU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12162736}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lwu OCA], [https://pdbe.org/1lwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lwu RCSB], [https://www.ebi.ac.uk/pdbsum/1lwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lwu ProSAT]</span></td></tr>
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[[1lwu]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWU OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIBA1_PETMA FIBA1_PETMA] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/1lwu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lwu ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Fibrinogen|Fibrinogen]]
*[[Fibrinogen|Fibrinogen]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012162736</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Petromyzon marinus]]
[[Category: Petromyzon marinus]]
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[[Category: Doolittle, R F.]]
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[[Category: Doolittle RF]]
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[[Category: Everse, S J.]]
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[[Category: Everse SJ]]
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[[Category: Pandi, L.]]
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[[Category: Pandi L]]
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[[Category: Riley, M.]]
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[[Category: Riley M]]
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[[Category: Spraggon, G.]]
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[[Category: Spraggon G]]
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[[Category: Yang, Z.]]
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[[Category: Yang Z]]
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[[Category: Blood clotting]]
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[[Category: Heterotrimer]]
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[[Category: Protein-peptide complex]]
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Current revision

Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide

PDB ID 1lwu

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