1k93

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[[Image:1k93.png|left|200px]]
 
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{{STRUCTURE_1k93| PDB=1k93 | SCENE= }}
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==Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin==
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<StructureSection load='1k93' size='340' side='right'caption='[[1k93]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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===Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k93]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Calmodulin'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_8 10.2210/rcsb_pdb/mom_2003_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K93 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11807546}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k93 OCA], [https://pdbe.org/1k93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k93 RCSB], [https://www.ebi.ac.uk/pdbsum/1k93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k93 ProSAT]</span></td></tr>
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[[1k93]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Calmodulin'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_8 10.2210/rcsb_pdb/mom_2003_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K93 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/1k93_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k93 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Adenylyl cyclase|Adenylyl cyclase]]
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*[[Anthrax edema factor 3D structures|Anthrax edema factor 3D structures]]
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*[[Calmodulin|Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011807546</ref><references group="xtra"/>
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[[Category: Adenylate cyclase]]
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Calmodulin]]
[[Category: Calmodulin]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Bard, J.]]
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[[Category: Bard J]]
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[[Category: Bohm, A.]]
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[[Category: Bohm A]]
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[[Category: Drum, C L.]]
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[[Category: Drum CL]]
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[[Category: Grabarek, Z.]]
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[[Category: Grabarek Z]]
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[[Category: Lu, D.]]
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[[Category: Lu D]]
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[[Category: Shen, Y Q.]]
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[[Category: Shen Y-Q]]
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[[Category: Soelaiman, S.]]
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[[Category: Soelaiman S]]
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[[Category: Tang, W J.]]
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[[Category: Tang W-J]]
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[[Category: Yan, S Z.]]
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[[Category: Yan S-Z]]
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[[Category: Adenylyl cyclase]]
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[[Category: Anthrax]]
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[[Category: Calmodulin]]
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[[Category: Edema factor]]
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[[Category: Lyase-metal binding protein complex]]
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[[Category: Toxin]]
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Current revision

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin

PDB ID 1k93

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