3ox1

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[[Image:3ox1.png|left|200px]]
 
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{{STRUCTURE_3ox1| PDB=3ox1 | SCENE= }}
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==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==
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<StructureSection load='3ox1' size='340' side='right'caption='[[3ox1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ox1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OX1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21538647}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=695:N-{2-[7-(METHYLSULFAMOYL)NAPHTHALEN-1-YL]ETHYL}ACETAMIDE'>695</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ox1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ox1 OCA], [https://pdbe.org/3ox1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ox1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ox1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ox1 ProSAT]</span></td></tr>
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[[3ox1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OX1 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
==See Also==
==See Also==
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*[[Quinone reductase|Quinone reductase]]
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021538647</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boutin, J A.]]
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[[Category: Large Structures]]
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[[Category: Delagrange, P.]]
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[[Category: Boutin JA]]
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[[Category: Ferry, G.]]
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[[Category: Delagrange P]]
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[[Category: Mesecar, A D.]]
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[[Category: Ferry G]]
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[[Category: Pegan, S D.]]
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[[Category: Mesecar AD]]
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[[Category: Sturdy, M.]]
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[[Category: Pegan SD]]
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[[Category: Fad]]
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[[Category: Sturdy M]]
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[[Category: Flavoprotein]]
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[[Category: Metal-2 binding]]
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[[Category: Nq02]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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[[Category: Qr2]]
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Current revision

X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values

PDB ID 3ox1

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