3o5n

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[[Image:3o5n.png|left|200px]]
 
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{{STRUCTURE_3o5n| PDB=3o5n | SCENE= }}
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==Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders==
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<StructureSection load='3o5n' size='340' side='right'caption='[[3o5n]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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===Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3o5n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O5N FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21626699}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR0:(3AS,4R,9BR)-9-NITRO-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA[C]QUINOLINE-4,6-DICARBOXYLIC+ACID'>BR0</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o5n OCA], [https://pdbe.org/3o5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o5n RCSB], [https://www.ebi.ac.uk/pdbsum/3o5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o5n ProSAT]</span></td></tr>
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[[3o5n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O5N OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SHAN3_MOUSE SHAN3_MOUSE] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.<ref>PMID:21423165</ref> <ref>PMID:21558424</ref> <ref>PMID:23739967</ref> <ref>PMID:24153177</ref>
==See Also==
==See Also==
*[[Shank protein|Shank protein]]
*[[Shank protein|Shank protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021626699</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Diehl, A.]]
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[[Category: Diehl A]]
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[[Category: Heinemann, U.]]
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[[Category: Heinemann U]]
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[[Category: Kamdem, N.]]
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[[Category: Kamdem N]]
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[[Category: Krause, G.]]
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[[Category: Krause G]]
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[[Category: Oschkinat, H.]]
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[[Category: Oschkinat H]]
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[[Category: Rademann, J.]]
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[[Category: Rademann J]]
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[[Category: Radetzki, S.]]
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[[Category: Radetzki S]]
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[[Category: Roske, Y.]]
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[[Category: Roske Y]]
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[[Category: Saupe, J.]]
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[[Category: Saupe J]]
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[[Category: Schillinger, C.]]
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[[Category: Schillinger C]]
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[[Category: Gkap]]
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[[Category: Pdz domain]]
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[[Category: Postsynaptic density]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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Current revision

Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders

PDB ID 3o5n

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