2wh7
From Proteopedia
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| - | [[Image:2wh7.png|left|200px]] | ||
| - | + | ==The partial structure of a group A streptpcoccal phage-encoded tail fibre hyaluronate lyase Hylp2== | |
| + | <StructureSection load='2wh7' size='340' side='right'caption='[[2wh7]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2wh7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WH7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wh7 OCA], [https://pdbe.org/2wh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wh7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wh7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q99ZZ7_STRP1 Q99ZZ7_STRP1] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/2wh7_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wh7 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structures of truncated forms of the Streptococcus pyogenes phage-encoded hyaluronate lyases HylP2 and HylP3 were determined by molecular replacement to 1.6 and 1.9 A resolution, respectively. The truncated forms crystallized in a hexagonal space group, forming a trimer around the threefold crystallographic axis. The arrangement of the fold is very similar to that observed in the structure of the related hyaluronate lyase HylP1. The structural elements putatively involved in substrate recognition are found to be conserved in both the HylP2 and HylP3 fragments. | ||
| - | + | Structures of two truncated phage-tail hyaluronate lyases from Streptococcus pyogenes serotype M1.,Martinez-Fleites C, Smith NL, Turkenburg JP, Black GW, Taylor EJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt, 10):963-6. Epub 2009 Sep 18. PMID:19850999<ref>PMID:19850999</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2wh7" style="background-color:#fffaf0;"></div> | |
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==See Also== | ==See Also== | ||
| - | *[[Hyaluronidase|Hyaluronidase]] | + | *[[Hyaluronidase 3D structures|Hyaluronidase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
[[Category: Streptococcus pyogenes]] | [[Category: Streptococcus pyogenes]] | ||
| - | [[Category: Black | + | [[Category: Black GW]] |
| - | [[Category: Martinez-Fleites | + | [[Category: Martinez-Fleites C]] |
| - | [[Category: Smith | + | [[Category: Smith NL]] |
| - | [[Category: Taylor | + | [[Category: Taylor EJ]] |
| - | [[Category: Turkenburg | + | [[Category: Turkenburg JP]] |
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Current revision
The partial structure of a group A streptpcoccal phage-encoded tail fibre hyaluronate lyase Hylp2
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