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2r9j

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[[Image:2r9j.png|left|200px]]
 
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{{STRUCTURE_2r9j| PDB=2r9j | SCENE= }}
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==Ligand recognition in C-lobe: The crystal structure of the complex of lactoferrin C-lobe with nicotinamide at 2.5 A resolution==
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<StructureSection load='2r9j' size='340' side='right'caption='[[2r9j]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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===Ligand recognition in C-lobe: The crystal structure of the complex of lactoferrin C-lobe with nicotinamide at 2.5 A resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[2r9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9J OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9j OCA], [https://pdbe.org/2r9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9j RCSB], [https://www.ebi.ac.uk/pdbsum/2r9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9j ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Lactoferrin|Lactoferrin]]
*[[Lactoferrin|Lactoferrin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Kaur, P.]]
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[[Category: Large Structures]]
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[[Category: Kumar, S.]]
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[[Category: Kaur P]]
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[[Category: Mir, R.]]
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[[Category: Kumar S]]
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[[Category: Sharma, S.]]
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[[Category: Mir R]]
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[[Category: Singh, N.]]
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[[Category: Sharma S]]
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[[Category: Singh, T P.]]
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[[Category: Singh N]]
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[[Category: Sinha, M.]]
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[[Category: Singh TP]]
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[[Category: Vikram, G.]]
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[[Category: Sinha M]]
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[[Category: Antibiotic]]
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[[Category: Vikram G]]
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[[Category: Antimicrobial]]
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[[Category: C-lobe]]
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[[Category: Complex]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Ion transport]]
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[[Category: Iron]]
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[[Category: Iron transport]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nicotinamide]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Transport]]
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Current revision

Ligand recognition in C-lobe: The crystal structure of the complex of lactoferrin C-lobe with nicotinamide at 2.5 A resolution

PDB ID 2r9j

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