3pn1
From Proteopedia
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| - | [[Image:3pn1.png|left|200px]] | ||
| - | + | ==Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo== | |
| - | + | <StructureSection load='3pn1' size='340' side='right'caption='[[3pn1]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3pn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PN1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVH:2-(BUTYLSULFANYL)ADENOSINE'>IVH</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pn1 OCA], [https://pdbe.org/3pn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pn1 RCSB], [https://www.ebi.ac.uk/pdbsum/3pn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pn1 ProSAT]</span></td></tr> |
| - | [[3pn1]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). | ||
==See Also== | ==See Also== | ||
| - | *[[DNA ligase|DNA ligase]] | + | *[[DNA ligase 3D structures|DNA ligase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Haemophilus influenzae]] | [[Category: Haemophilus influenzae]] | ||
| - | [[Category: Buurman | + | [[Category: Large Structures]] |
| - | [[Category: Eakin | + | [[Category: Buurman E]] |
| - | [[Category: Gao | + | [[Category: Eakin A]] |
| - | [[Category: Huynh | + | [[Category: Gao N]] |
| - | [[Category: Johnson | + | [[Category: Huynh H]] |
| - | [[Category: Lahiri | + | [[Category: Johnson K]] |
| - | [[Category: Mills | + | [[Category: Lahiri S]] |
| - | [[Category: Newman | + | [[Category: Mills S]] |
| - | [[Category: Shapiro | + | [[Category: Newman J]] |
| - | [[Category: Stokes | + | [[Category: Shapiro A]] |
| - | [[Category: Walkup | + | [[Category: Stokes S]] |
| - | [[Category: Wei | + | [[Category: Walkup G]] |
| - | + | [[Category: Wei Y]] | |
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Current revision
Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo
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Categories: Haemophilus influenzae | Large Structures | Buurman E | Eakin A | Gao N | Huynh H | Johnson K | Lahiri S | Mills S | Newman J | Shapiro A | Stokes S | Walkup G | Wei Y
