1bgo

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[[Image:1bgo.png|left|200px]]
 
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{{STRUCTURE_1bgo| PDB=1bgo | SCENE= }}
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==CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR==
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<StructureSection load='1bgo' size='340' side='right'caption='[[1bgo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bgo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I10:1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE'>I10</scene></td></tr>
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[[1bgo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGO OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgo OCA], [https://pdbe.org/1bgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgo RCSB], [https://www.ebi.ac.uk/pdbsum/1bgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgo ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/1bgo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bgo ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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[[Category: Cathepsin K]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Abdel-Meguid, S S.]]
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[[Category: Large Structures]]
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[[Category: Alessio, K D.]]
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[[Category: Abdel-Meguid SS]]
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[[Category: Allen, A C.]]
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[[Category: Allen AC]]
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[[Category: Bondinell, W E.]]
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[[Category: Bondinell WE]]
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[[Category: Desjarlais, R L.]]
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[[Category: D'Alessio K]]
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[[Category: Erhard, K F.]]
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[[Category: Desjarlais RL]]
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[[Category: Haltiwanger, R C.]]
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[[Category: Erhard KF]]
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[[Category: Janson, C A.]]
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[[Category: Haltiwanger RC]]
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[[Category: Levy, M A.]]
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[[Category: Janson CA]]
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[[Category: Mcqueney, M S.]]
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[[Category: Levy MA]]
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[[Category: Oh, H J.]]
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[[Category: Mcqueney MS]]
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[[Category: Smith, W W.]]
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[[Category: Oh H-J]]
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[[Category: Tomaszek, T A.]]
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[[Category: Smith WW]]
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[[Category: Uzinskas, I N.]]
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[[Category: Tomaszek TA]]
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[[Category: Veber, D F.]]
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[[Category: Uzinskas IN]]
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[[Category: Yamashita, D S.]]
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[[Category: Veber DF]]
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[[Category: Zhao, B.]]
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[[Category: Yamashita DS]]
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[[Category: Hydrolase]]
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[[Category: Zhao B]]
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[[Category: Sulfhydryl proteinase]]
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[[Category: Thiol protease]]
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Current revision

CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR

PDB ID 1bgo

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