2ozr

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[[Image:2ozr.png|left|200px]]
 
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{{STRUCTURE_2ozr| PDB=2ozr | SCENE= }}
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==MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid==
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<StructureSection load='2ozr' size='340' side='right'caption='[[2ozr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ozr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OZR FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17623656}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GG1:4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC+ACID'>GG1</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ozr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ozr OCA], [https://pdbe.org/2ozr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ozr RCSB], [https://www.ebi.ac.uk/pdbsum/2ozr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ozr ProSAT]</span></td></tr>
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[[2ozr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OZR OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN] Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:[https://omim.org/entry/602111 602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.<ref>PMID:16167086</ref> Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:[https://omim.org/entry/602111 602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.<ref>PMID:19615667</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN] Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/2ozr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ozr ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017623656</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banotai, C A.]]
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[[Category: Large Structures]]
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[[Category: Baragi, V.]]
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[[Category: Banotai CA]]
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[[Category: Bornemeier, D A.]]
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[[Category: Baragi V]]
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[[Category: Datta, K.]]
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[[Category: Bornemeier DA]]
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[[Category: Dyer, R D.]]
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[[Category: Datta K]]
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[[Category: Fasquelle, V.]]
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[[Category: Dyer RD]]
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[[Category: Guzman, R.]]
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[[Category: Fasquelle V]]
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[[Category: Han, H K.]]
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[[Category: Guzman R]]
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[[Category: Johnson, A R.]]
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[[Category: Han H-K]]
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[[Category: Lesch, C.]]
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[[Category: Johnson AR]]
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[[Category: Lie, J J.]]
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[[Category: Lesch C]]
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[[Category: Man, C F.]]
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[[Category: Lie JJ]]
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[[Category: McConnell, P.]]
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[[Category: Man C-F]]
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[[Category: Mueller, W T.]]
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[[Category: McConnell P]]
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[[Category: Ortwine, D F.]]
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[[Category: Mueller WT]]
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[[Category: Pavlovsky, A G.]]
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[[Category: Ortwine DF]]
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[[Category: Prior, F.]]
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[[Category: Pavlovsky AG]]
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[[Category: Roark, W H.]]
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[[Category: Prior F]]
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[[Category: Robertson, D.]]
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[[Category: Roark WH]]
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[[Category: Wilson, M.]]
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[[Category: Robertson D]]
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[[Category: Yan, C H.]]
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[[Category: Wilson M]]
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[[Category: Crystal complex structure]]
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[[Category: Yan CH]]
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[[Category: Hydrolase]]
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[[Category: Matrix metalloproteinase]]
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[[Category: Mmp13 catalytic domain]]
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[[Category: Mmp13 specific inhibitor]]
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Current revision

MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid

PDB ID 2ozr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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