2ky6

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[[Image:2ky6.png|left|200px]]
 
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{{STRUCTURE_2ky6| PDB=2ky6 | SCENE= }}
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==Structure of ARC92VBD/MED25ACID==
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<StructureSection load='2ky6' size='340' side='right'caption='[[2ky6]]' scene=''>
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===Structure of ARC92VBD/MED25ACID===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ky6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KY6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21378963}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ky6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ky6 OCA], [https://pdbe.org/2ky6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ky6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ky6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ky6 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2ky6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KY6 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Charcot-Marie-Tooth disease type 2B2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19290556</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.<ref>PMID:14657022</ref> <ref>PMID:14983011</ref> <ref>PMID:17641689</ref>
==See Also==
==See Also==
*[[Mediator|Mediator]]
*[[Mediator|Mediator]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021378963</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Milbradt, A G.]]
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[[Category: Large Structures]]
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[[Category: Naar, A M.]]
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[[Category: Milbradt AG]]
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[[Category: Selenko, P.]]
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[[Category: Naar AM]]
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[[Category: Sun, Z J.]]
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[[Category: Selenko P]]
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[[Category: Takeuchi, K.]]
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[[Category: Sun ZJ]]
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[[Category: Wagner, G.]]
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[[Category: Takeuchi K]]
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[[Category: Acid]]
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[[Category: Wagner G]]
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[[Category: Arc]]
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[[Category: Mediator]]
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[[Category: Transcription regulator]]
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[[Category: Vp16 binding domain]]
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Current revision

Structure of ARC92VBD/MED25ACID

PDB ID 2ky6

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