2oum
From Proteopedia
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| - | [[Image:2oum.png|left|200px]] | ||
| - | + | ==The first domain of L1 from Thermus thermophilus== | |
| - | + | <StructureSection load='2oum' size='340' side='right'caption='[[2oum]], [[Resolution|resolution]] 2.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2oum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oum OCA], [https://pdbe.org/2oum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oum RCSB], [https://www.ebi.ac.uk/pdbsum/2oum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oum ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2oum]] is a 1 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/RL1_THET8 RL1_THET8] Directly binds to 23S rRNA. Forms what is known as the L1 stalk, which protrudes beyond the 70S ribosome surface. The stalk is preferentially stabilized in 70S versus 50S crystals. Interacts with the E site tRNA, blocking the exit path. This blockage implies that this section of the ribosome must be able to move to release the deacetylated tRNA.[HAMAP-Rule:MF_01318_B] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318_B] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2oum_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oum ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Ribosomal protein L1|Ribosomal protein L1]] | *[[Ribosomal protein L1|Ribosomal protein L1]] | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
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| - | [[Category: | + | |
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| + | [[Category: Davydova N]] | ||
| + | [[Category: Garber M]] | ||
| + | [[Category: Kljashtorny V]] | ||
| + | [[Category: Nevskaya N]] | ||
| + | [[Category: Nikonov S]] | ||
| + | [[Category: Tishchenko S]] | ||
Current revision
The first domain of L1 from Thermus thermophilus
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