1rkc

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[[Image:1rkc.png|left|200px]]
 
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{{STRUCTURE_1rkc| PDB=1rkc | SCENE= }}
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==Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)==
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<StructureSection load='1rkc' size='340' side='right'caption='[[1rkc]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rkc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RKC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14702644}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rkc OCA], [https://pdbe.org/1rkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rkc RCSB], [https://www.ebi.ac.uk/pdbsum/1rkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rkc ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1rkc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKC OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:[https://omim.org/entry/611407 611407]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:11815424</ref> <ref>PMID:16236538</ref> Defects in VCL are the cause of familial hypertrophic cardiomyopathy type 15 (CMH15) [MIM:[https://omim.org/entry/613255 613255]. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:16712796</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:20484056</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rk/1rkc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rkc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Talin|Talin]]
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*[[Talin 3D structures|Talin 3D structures]]
*[[Vinculin|Vinculin]]
*[[Vinculin|Vinculin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014702644</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bois, P R.]]
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[[Category: Large Structures]]
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[[Category: Borgon, R A.]]
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[[Category: Bois PR]]
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[[Category: Bricogne, G.]]
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[[Category: Borgon RA]]
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[[Category: Evans, G.]]
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[[Category: Bricogne G]]
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[[Category: Izard, T.]]
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[[Category: Evans G]]
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[[Category: Rush, C L.]]
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[[Category: Izard T]]
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[[Category: Actin-binding]]
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[[Category: Rush CL]]
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[[Category: Cell adhesion]]
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[[Category: Cytoskeleton]]
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[[Category: Structural protein]]
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[[Category: X-ray crystallography]]
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Current revision

Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)

PDB ID 1rkc

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