1dfq

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[[Image:1dfq.png|left|200px]]
 
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{{STRUCTURE_1dfq| PDB=1dfq | SCENE= }}
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==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID==
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<StructureSection load='1dfq' size='340' side='right'caption='[[1dfq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dfq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DFQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10722735}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfq OCA], [https://pdbe.org/1dfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dfq RCSB], [https://www.ebi.ac.uk/pdbsum/1dfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dfq ProSAT]</span></td></tr>
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[[1dfq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1dfq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dfq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Tetanus toxin|Tetanus toxin]]
*[[Tetanus toxin|Tetanus toxin]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010722735</ref><references group="xtra"/>
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[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
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[[Category: Tentoxilysin]]
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[[Category: Large Structures]]
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[[Category: Black, I.]]
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[[Category: Black I]]
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[[Category: Charles, I G.]]
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[[Category: Charles IG]]
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[[Category: Emsley, P.]]
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[[Category: Emsley P]]
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[[Category: Fairweather, N F.]]
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[[Category: Fairweather NF]]
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[[Category: Fotinou, C.]]
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[[Category: Fotinou C]]
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[[Category: Hewitt, E.]]
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[[Category: Hewitt E]]
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[[Category: Isaacs, N W.]]
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[[Category: Isaacs NW]]
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[[Category: Watts, C.]]
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[[Category: Watts C]]
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[[Category: Beta trefoil]]
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[[Category: Carbohydrate]]
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[[Category: Jelly-roll]]
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[[Category: Toxin]]
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Current revision

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID

PDB ID 1dfq

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