1z8u
From Proteopedia
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| - | [[Image:1z8u.png|left|200px]] | ||
| - | + | ==Crystal structure of oxidized alpha hemoglobin bound to AHSP== | |
| - | + | <StructureSection load='1z8u' size='340' side='right'caption='[[1z8u]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1z8u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8U FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8u OCA], [https://pdbe.org/1z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8u RCSB], [https://www.ebi.ac.uk/pdbsum/1z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8u ProSAT]</span></td></tr> |
| - | [[1z8u]] is a 4 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AHSP_HUMAN AHSP_HUMAN] Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<ref>PMID:12066189</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8u_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8u ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Hemoglobin|Hemoglobin]] | + | *[[Hemoglobin 3D structures|Hemoglobin 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Feng | + | [[Category: Large Structures]] |
| - | [[Category: Gell | + | [[Category: Feng L]] |
| - | [[Category: Gow | + | [[Category: Gell DA]] |
| - | [[Category: Gu | + | [[Category: Gow AJ]] |
| - | [[Category: Mackay | + | [[Category: Gu L]] |
| - | [[Category: Shi | + | [[Category: Mackay JP]] |
| - | [[Category: Weiss | + | [[Category: Shi Y]] |
| - | [[Category: Zhou | + | [[Category: Weiss MJ]] |
| - | + | [[Category: Zhou S]] | |
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Current revision
Crystal structure of oxidized alpha hemoglobin bound to AHSP
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Categories: Homo sapiens | Large Structures | Feng L | Gell DA | Gow AJ | Gu L | Mackay JP | Shi Y | Weiss MJ | Zhou S
