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1jnj

From Proteopedia

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[[Image:1jnj.png|left|200px]]
 
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{{STRUCTURE_1jnj| PDB=1jnj | SCENE= }}
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==NMR solution structure of the human beta2-microglobulin==
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<StructureSection load='1jnj' size='340' side='right'caption='[[1jnj]]' scene=''>
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===NMR solution structure of the human beta2-microglobulin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jnj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11847272}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnj OCA], [https://pdbe.org/1jnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnj RCSB], [https://www.ebi.ac.uk/pdbsum/1jnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnj ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1jnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNJ OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnj ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011847272</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Andreola, A.]]
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[[Category: Large Structures]]
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[[Category: Bellotti, V.]]
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[[Category: Andreola A]]
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[[Category: Corazza, A.]]
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[[Category: Bellotti V]]
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[[Category: Esposito, G.]]
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[[Category: Corazza A]]
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[[Category: Giorgetti, S.]]
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[[Category: Esposito G]]
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[[Category: Mangione, P.]]
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[[Category: Giorgetti S]]
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[[Category: Pettirossi, F.]]
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[[Category: Mangione P]]
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[[Category: Stoppini, M.]]
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[[Category: Pettirossi F]]
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[[Category: Verdone, G.]]
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[[Category: Stoppini M]]
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[[Category: Viglino, P.]]
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[[Category: Verdone G]]
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[[Category: Immune system]]
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[[Category: Viglino P]]
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[[Category: Immunoglobulin constant domain]]
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Current revision

NMR solution structure of the human beta2-microglobulin

PDB ID 1jnj

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