3mdy

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[[Image:3mdy.png|left|200px]]
 
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{{STRUCTURE_3mdy| PDB=3mdy | SCENE= }}
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==Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189==
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<StructureSection load='3mdy' size='340' side='right'caption='[[3mdy]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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===Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mdy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MDY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDN:4-[6-(4-PIPERAZIN-1-YLPHENYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]QUINOLINE'>LDN</scene></td></tr>
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[[3mdy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDY OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdy OCA], [https://pdbe.org/3mdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mdy RCSB], [https://www.ebi.ac.uk/pdbsum/3mdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdy ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BMR1B_HUMAN BMR1B_HUMAN] Brachydactyly type A2;Brachydactyly type C;Acromesomelic dysplasia, Grebe type. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/BMR1B_HUMAN BMR1B_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mdy ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclophilin|Cyclophilin]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein serine/threonine kinase]]
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[[Category: Large Structures]]
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[[Category: Alfano, I.]]
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[[Category: Alfano I]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Bullock, A.]]
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[[Category: Bullock A]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad A]]
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[[Category: Cooper, C.]]
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[[Category: Cooper C]]
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[[Category: Daga, N.]]
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[[Category: Daga N]]
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[[Category: Delft, F von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Krojer T]]
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[[Category: Krojer, T.]]
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[[Category: Mahajan P]]
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[[Category: Mahajan, P.]]
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[[Category: Sanvitale C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weigelt J]]
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[[Category: Sanvitale, C.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: Atp-binding]]
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[[Category: Disease mutation]]
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[[Category: Kinase]]
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[[Category: Receptor serine/threonine kinase]]
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[[Category: Rotamase]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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[[Category: Transferase-isomerase complex]]
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Current revision

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189

PDB ID 3mdy

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