3r84
From Proteopedia
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| - | [[Image:3r84.png|left|200px]] | ||
| - | + | ==Structure of the Mediator head subcomplex Med11/22== | |
| + | <StructureSection load='3r84' size='340' side='right'caption='[[3r84]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3r84]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R84 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r84 OCA], [https://pdbe.org/3r84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r84 RCSB], [https://www.ebi.ac.uk/pdbsum/3r84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r84 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mediator is a multiprotein co-activator of RNA polymerase (Pol) II transcription. Mediator contains a conserved core that comprises the 'head' and 'middle' modules. We present here a structure-function analysis of the essential Med11/22 heterodimer, a part of the head module. Med11/22 forms a conserved four-helix bundle domain with C-terminal extensions, which bind the central head subunit Med17. A highly conserved patch on the bundle surface is required for stable transcription pre-initiation complex formation on a Pol II promoter in vitro and in vivo and may recruit the general transcription factor TFIIH. The bundle domain fold is also present in the Mediator middle module subcomplex Med7/21 and is predicted in the Mediator heterodimers Med2/3, Med4/9, Med10/14 and Med28/30. The bundle domain thus represents a common building block that has been multiplied and functionally diversified during Mediator evolution in eukaryotes. | ||
| - | + | Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.,Seizl M, Lariviere L, Pfaffeneder T, Wenzeck L, Cramer P Nucleic Acids Res. 2011 Apr 15. PMID:21498544<ref>PMID:21498544</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3r84" style="background-color:#fffaf0;"></div> | |
| - | + | ||
==See Also== | ==See Also== | ||
*[[Mediator|Mediator]] | *[[Mediator|Mediator]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Cramer | + | [[Category: Cramer P]] |
| - | [[Category: Lariviere | + | [[Category: Lariviere L]] |
| - | [[Category: Pfaffenender | + | [[Category: Pfaffenender T]] |
| - | [[Category: Seizl | + | [[Category: Seizl M]] |
| - | [[Category: Wenzeck | + | [[Category: Wenzeck L]] |
| - | + | ||
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Current revision
Structure of the Mediator head subcomplex Med11/22
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