1ycr

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[[Image:1ycr.png|left|200px]]
 
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{{STRUCTURE_1ycr| PDB=1ycr | SCENE= }}
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==MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53==
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<StructureSection load='1ycr' size='340' side='right'caption='[[1ycr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ycr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YCR FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8875929}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ycr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycr OCA], [https://pdbe.org/1ycr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ycr RCSB], [https://www.ebi.ac.uk/pdbsum/1ycr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ycr ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1ycr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCR OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
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== Function ==
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[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1ycr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ycr ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[MDM2|MDM2]]
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*[[MDM2 3D structures|MDM2 3D structures]]
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*[[P53|P53]]
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*[[P53 3D structures|P53 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008875929</ref><ref group="xtra">PMID:014695246</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kussie, P H.]]
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[[Category: Large Structures]]
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[[Category: Pavletich, N P.]]
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[[Category: Kussie PH]]
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[[Category: Activator]]
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[[Category: Pavletich NP]]
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[[Category: Anti-oncogene]]
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[[Category: Dna-binding]]
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[[Category: Nuclear protein]]
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[[Category: Phosphorylation]]
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[[Category: Transcription regulation]]
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Current revision

MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53

PDB ID 1ycr

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