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2xg3

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[[Image:2xg3.png|left|200px]]
 
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{{STRUCTURE_2xg3| PDB=2xg3 | SCENE= }}
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==Human galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitor==
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<StructureSection load='2xg3' size='340' side='right'caption='[[2xg3]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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===HUMAN GALECTIN-3 IN COMPLEX WITH A BENZAMIDO-N-ACETYLLACTOSEAMINE INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XG3 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20873837}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNU:BENZAMIDE'>UNU</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg3 OCA], [https://pdbe.org/2xg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xg3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg3 ProSAT]</span></td></tr>
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[[2xg3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG3 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
==See Also==
==See Also==
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*[[Galectin|Galectin]]
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020873837</ref><references group="xtra"/>
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__TOC__
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[[Category: Akke, M.]]
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</StructureSection>
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[[Category: Delaine, T.]]
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[[Category: Homo sapiens]]
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[[Category: Diehl, C.]]
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[[Category: Large Structures]]
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[[Category: Engstrom, O.]]
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[[Category: Akke M]]
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[[Category: Genheden, S.]]
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[[Category: Delaine T]]
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[[Category: Hakansson, M.]]
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[[Category: Diehl C]]
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[[Category: Leffler, H.]]
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[[Category: Engstrom O]]
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[[Category: Modig, K.]]
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[[Category: Genheden S]]
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[[Category: Nilsson, U.]]
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[[Category: Hakansson M]]
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[[Category: Ryde, U.]]
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[[Category: Leffler H]]
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[[Category: Ige-binding protein]]
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[[Category: Modig K]]
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[[Category: Lectin]]
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[[Category: Nilsson U]]
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[[Category: Sugar binding protein]]
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[[Category: Ryde U]]

Current revision

Human galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitor

PDB ID 2xg3

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