3b29

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[[Image:3b29.png|left|200px]]
 
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{{STRUCTURE_3b29| PDB=3b29 | SCENE= }}
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==Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside==
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<StructureSection load='3b29' size='340' side='right'caption='[[3b29]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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===Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B29 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22139193}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LSM:DODECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-1-SELENO-BETA-D-GLUCOPYRANOSIDE'>LSM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b29 OCA], [https://pdbe.org/3b29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b29 RCSB], [https://www.ebi.ac.uk/pdbsum/3b29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b29 ProSAT]</span></td></tr>
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[[3b29]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B29 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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== Function ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
==See Also==
==See Also==
*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022139193</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ago, H.]]
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[[Category: Large Structures]]
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[[Category: Miyano, M.]]
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[[Category: Ago H]]
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[[Category: Saino, H.]]
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[[Category: Miyano M]]
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[[Category: Helix bundle]]
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[[Category: Saino H]]
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[[Category: Homo trimer]]
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[[Category: Lyase]]
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[[Category: Mapeg]]
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[[Category: Membrane protein]]
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[[Category: Mgst]]
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Current revision

Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside

PDB ID 3b29

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