1jiz

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[[Image:1jiz.png|left|200px]]
 
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{{STRUCTURE_1jiz| PDB=1jiz | SCENE= }}
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==Crystal Structure Analysis of human Macrophage Elastase MMP-12==
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<StructureSection load='1jiz' size='340' side='right'caption='[[1jiz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Crystal Structure Analysis of human Macrophage Elastase MMP-12===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jiz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JIZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11575929}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGS:N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE+HYDROCHLORIDE'>CGS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jiz OCA], [https://pdbe.org/1jiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jiz RCSB], [https://www.ebi.ac.uk/pdbsum/1jiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jiz ProSAT]</span></td></tr>
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[[1jiz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIZ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/1jiz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jiz ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Elastase|Elastase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011575929</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Large Structures]]
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[[Category: Bauer, M M.T.]]
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[[Category: Bauer MMT]]
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[[Category: Dollinger, H.]]
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[[Category: Dollinger H]]
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[[Category: Jung, B.]]
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[[Category: Jung B]]
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[[Category: Nar, H.]]
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[[Category: Nar H]]
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[[Category: Werle, K.]]
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[[Category: Werle K]]
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[[Category: Chronic obstructive pulmonary disease]]
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[[Category: Hydrolase]]
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[[Category: Matrix metalloproteinase]]
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[[Category: Mmp-12]]
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Current revision

Crystal Structure Analysis of human Macrophage Elastase MMP-12

PDB ID 1jiz

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