3gtd

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[[Image:3gtd.png|left|200px]]
 
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{{STRUCTURE_3gtd| PDB=3gtd | SCENE= }}
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==2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii==
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<StructureSection load='3gtd' size='340' side='right'caption='[[3gtd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_prowazekii_str._Madrid_E Rickettsia prowazekii str. Madrid E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GTD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [https://pdbe.org/3gtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [https://www.ebi.ac.uk/pdbsum/3gtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gtd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FUMC_RICPR FUMC_RICPR] Catalyzes the reversible addition of water to fumarate to give L-malate (By similarity).[HAMAP-Rule:MF_00743]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/3gtd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gtd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rickettsiae are obligate intracellular parasites of eukaryotic cells that are the causative agents responsible for spotted fever and typhus. Their small genome (about 800 protein-coding genes) is highly conserved across species and has been postulated as the ancestor of the mitochondria. No genes that are required for glycolysis are found in the Rickettsia prowazekii or mitochondrial genomes, but a complete set of genes encoding components of the tricarboxylic acid cycle and the respiratory-chain complex is found in both. A 2.4 A resolution crystal structure of R. prowazekii fumarate hydratase, an enzyme catalyzing the third step of the tricarboxylic acid cycle pathway that ultimately converts phosphoenolpyruvate into succinyl-CoA, has been solved. A structure alignment with human mitochondrial fumarate hydratase highlights the close similarity between R. prowazekii and mitochondrial enzymes.
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===2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii===
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Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria.,Phan I, Subramanian S, Olsen C, Edwards TE, Guo W, Zhang Y, Van Voorhis WC, Stewart LJ, Myler PJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1123-8. Epub 2011 Aug 16. PMID:21904061<ref>PMID:21904061</ref>
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{{ABSTRACT_PUBMED_21904061}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3gtd" style="background-color:#fffaf0;"></div>
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[[3gtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA].
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==See Also==
==See Also==
*[[Fumarase|Fumarase]]
*[[Fumarase|Fumarase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021904061</ref><references group="xtra"/>
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__TOC__
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[[Category: Fumarate hydratase]]
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</StructureSection>
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[[Category: Rickettsia prowazekii]]
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[[Category: Large Structures]]
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[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
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[[Category: Rickettsia prowazekii str. Madrid E]]
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[[Category: Fumarate]]
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[[Category: Hydratase]]
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[[Category: Lyase]]
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[[Category: Seattle structural genomics center for infectious disease]]
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[[Category: Ssgcid]]
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[[Category: Structural genomic]]
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[[Category: Tricarboxylic acid cycle]]
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Current revision

2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii

PDB ID 3gtd

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