1mtl
From Proteopedia
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| - | [[Image:1mtl.jpg|left|200px]]<br /><applet load="1mtl" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1mtl, resolution 2.80Å" /> | ||
| - | '''Non-productive MUG-DNA complex'''<br /> | ||
| - | == | + | ==Non-productive MUG-DNA complex== |
| - | + | <StructureSection load='1mtl' size='340' side='right'caption='[[1mtl]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1mtl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MTL FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AAB:2-DEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>AAB</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mtl OCA], [https://pdbe.org/1mtl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mtl RCSB], [https://www.ebi.ac.uk/pdbsum/1mtl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mtl ProSAT]</span></td></tr> |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MUG_ECOLI MUG_ECOLI] Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.<ref>PMID:8878487</ref> <ref>PMID:12668677</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/1mtl_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mtl ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Barlow | + | [[Category: Barlow T]] |
| - | [[Category: Barrett | + | [[Category: Barrett TE]] |
| - | [[Category: Brown | + | [[Category: Brown T]] |
| - | [[Category: Jiricny | + | [[Category: Jiricny J]] |
| - | [[Category: Pearl | + | [[Category: Pearl LH]] |
| - | [[Category: Savva | + | [[Category: Savva R]] |
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Current revision
Non-productive MUG-DNA complex
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Categories: Escherichia coli | Large Structures | Barlow T | Barrett TE | Brown T | Jiricny J | Pearl LH | Savva R
