2yfy

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[[Image:2yfy.png|left|200px]]
 
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{{STRUCTURE_2yfy| PDB=2yfy | SCENE= }}
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==SERCA in the HnE2 State Complexed With Debutanoyl Thapsigargin==
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<StructureSection load='2yfy' size='340' side='right'caption='[[2yfy]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2yfy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YFY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9TN:DEBUTANOYL+THAPSIGARGIN'>9TN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yfy OCA], [https://pdbe.org/2yfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yfy RCSB], [https://www.ebi.ac.uk/pdbsum/2yfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yfy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structural elucidation of membrane proteins continues to gather pace, but we know little about their molecular interactions with the lipid environment or how they interact with the surrounding bilayer. Here, with the aid of low-resolution X-ray crystallography, we present direct structural information on membrane interfaces as delineated by lipid phosphate groups surrounding the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) in its phosphorylated and dephosphorylated Ca(2+)-free forms. The protein-lipid interactions are further analysed using molecular dynamics simulations. We find that SERCA adapts to membranes of different hydrophobic thicknesses by inducing local deformations in the lipid bilayers and by undergoing small rearrangements of the amino-acid side chains and helix tilts. These mutually adaptive interactions allow smooth transitions through large conformational changes associated with the transport cycle of SERCA, a strategy that may be of general nature for many membrane proteins.
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===SERCA IN THE HNE2 STATE COMPLEXED WITH DEBUTANOYL THAPSIGARGIN===
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Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes.,Sonntag Y, Musgaard M, Olesen C, Schiott B, Moller JV, Nissen P, Thogersen L Nat Commun. 2011;2:304. PMID:21556058<ref>PMID:21556058</ref>
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{{ABSTRACT_PUBMED_21556058}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2yfy" style="background-color:#fffaf0;"></div>
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[[2yfy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YFY OCA].
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==See Also==
==See Also==
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*[[ATPase|ATPase]]
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021556058</ref><references group="xtra"/>
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__TOC__
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[[Category: Calcium-transporting ATPase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Moller, J V.]]
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[[Category: Moller JV]]
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[[Category: Musgaard, M.]]
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[[Category: Musgaard M]]
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[[Category: Nissen, P.]]
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[[Category: Nissen P]]
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[[Category: Olesen, C.]]
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[[Category: Olesen C]]
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[[Category: Schiott, B.]]
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[[Category: Schiott B]]
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[[Category: Sonntag, Y.]]
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[[Category: Sonntag Y]]
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[[Category: Thogersen, L.]]
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[[Category: Thogersen L]]
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[[Category: Hydrolase]]
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[[Category: Ion transport]]
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[[Category: Membrane protein]]
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[[Category: P-type atpase]]
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[[Category: Prostate cancer]]
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[[Category: Serca]]
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Current revision

SERCA in the HnE2 State Complexed With Debutanoyl Thapsigargin

PDB ID 2yfy

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