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3oyw

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[[Image:3oyw.png|left|200px]]
 
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{{STRUCTURE_3oyw| PDB=3oyw | SCENE= }}
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==Crystal structure of human galectin-1 in complex with thiodigalactoside==
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<StructureSection load='3oyw' size='340' side='right'caption='[[3oyw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of human galectin-1 in complex with thiodigalactoside===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OYW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20826047}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900027:thiodigalactoside'>PRD_900027</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [https://pdbe.org/3oyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [https://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>
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[[3oyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
==See Also==
==See Also==
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*[[Galectin|Galectin]]
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020826047</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blanchard, H.]]
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[[Category: Large Structures]]
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[[Category: Collins, P M.]]
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[[Category: Blanchard H]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Collins PM]]
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[[Category: Galectin]]
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[[Category: Lactobionic acid]]
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Current revision

Crystal structure of human galectin-1 in complex with thiodigalactoside

PDB ID 3oyw

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