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1i02

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[[Image:1i02.png|left|200px]]
 
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{{STRUCTURE_1i02| PDB=1i02 | SCENE= }}
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==NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)==
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<StructureSection load='1i02' size='340' side='right'caption='[[1i02]]' scene=''>
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===NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1i02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I02 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11669614}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i02 OCA], [https://pdbe.org/1i02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i02 RCSB], [https://www.ebi.ac.uk/pdbsum/1i02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i02 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1i02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/3SA3_NAJAT 3SA3_NAJAT] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells (PubMed:8182052). Interaction with sulfatides in the cell membrane induces pore formation and cell internalization. Cytotoxicity is due to pore formation, and to another mechanism independent of membrane-damaging activity. When internalized, it targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. It inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity (PubMed:16407244). It also binds with high affinity to heparin (PubMed:17685633).<ref>PMID:15922335</ref> <ref>PMID:16263708</ref> <ref>PMID:16407244</ref> <ref>PMID:17714752</ref> <ref>PMID:8182052</ref> <ref>PMID:8448165</ref> <ref>PMID:9245415</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/1i02_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i02 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cardiotoxin|Cardiotoxin]]
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*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011669614</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Naja atra]]
[[Category: Naja atra]]
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[[Category: Harold, J.]]
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[[Category: Harold J]]
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[[Category: Sue, S C.]]
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[[Category: Sue S-C]]
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[[Category: Wu, W g.]]
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[[Category: Wu W-g]]
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[[Category: Bound water]]
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[[Category: Cardiotoxin]]
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[[Category: Ctx]]
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[[Category: Cytotoxin]]
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[[Category: Gag binding protein]]
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[[Category: Hemolysis]]
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[[Category: Membrane binding protein]]
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[[Category: Three-finger type]]
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[[Category: Toxin]]
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Current revision

NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)

PDB ID 1i02

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