3aam

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[[Image:3aam.png|left|200px]]
 
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{{STRUCTURE_3aam| PDB=3aam | SCENE= }}
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==Crystal structure of endonuclease IV from Thermus thermophilus HB8==
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<StructureSection load='3aam' size='340' side='right'caption='[[3aam]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3aam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AAM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aam OCA], [https://pdbe.org/3aam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aam RCSB], [https://www.ebi.ac.uk/pdbsum/3aam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aam ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5SK18_THET8 Q5SK18_THET8]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Endonuclease IV (EndoIV) is an endonuclease that acts at apurinic/apyrimidinic (AP) sites and is classified as either long-type or short-type. The crystal structures of representative types of EndoIV from Geobacillus kaustophilus and Thermus thermophilus HB8 were determined using X-ray crystallography. G. kaustophilus EndoIV (the long type) had a higher affinity for double-stranded DNA containing an AP-site analogue than T. thermophilus EndoIV (the short type). Structural analysis of the two different EndoIVs suggested that a C-terminal DNA-recognition loop that is only present in the long type contributes to its high affinity for AP sites. A mutation analysis showed that Lys267 in the C-terminal DNA-recognition loop plays an important role in DNA binding.
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===Crystal structure of endonuclease IV from Thermus thermophilus HB8===
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An additional C-terminal loop in endonuclease IV, an apurinic/apyrimidinic endonuclease, controls binding affinity to DNA.,Asano R, Ishikawa H, Nakane S, Nakagawa N, Kuramitsu S, Masui R Acta Crystallogr D Biol Crystallogr. 2011 Mar;67(Pt 3):149-55. Epub 2011, Feb 15. PMID:21358045<ref>PMID:21358045</ref>
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{{ABSTRACT_PUBMED_21358045}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3aam" style="background-color:#fffaf0;"></div>
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[[3aam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AAM OCA].
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==See Also==
==See Also==
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*[[Endonuclease|Endonuclease]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021358045</ref><references group="xtra"/>
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__TOC__
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[[Category: Thermus thermophilus]]
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</StructureSection>
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[[Category: Asano, R.]]
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[[Category: Large Structures]]
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[[Category: Baba, S.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ishikawa, H.]]
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[[Category: Asano R]]
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[[Category: Kuramitsu, S.]]
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[[Category: Baba S]]
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[[Category: Masui, R.]]
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[[Category: Ishikawa H]]
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[[Category: Nakagawa, N.]]
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[[Category: Kuramitsu S]]
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[[Category: Nakane, S.]]
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[[Category: Masui R]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nakagawa N]]
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[[Category: Base excision repair]]
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[[Category: Nakane S]]
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[[Category: Ber]]
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[[Category: Dna repair]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tim barrel]]
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Current revision

Crystal structure of endonuclease IV from Thermus thermophilus HB8

PDB ID 3aam

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