1nhz

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[[Image:1nhz.png|left|200px]]
 
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{{STRUCTURE_1nhz| PDB=1nhz | SCENE= }}
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==Crystal Structure of the Antagonist Form of Glucocorticoid Receptor==
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<StructureSection load='1nhz' size='340' side='right'caption='[[1nhz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal Structure of the Antagonist Form of Glucocorticoid Receptor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NHZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12686538}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=486:11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC+AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE'>486</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nhz OCA], [https://pdbe.org/1nhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nhz RCSB], [https://www.ebi.ac.uk/pdbsum/1nhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nhz ProSAT]</span></td></tr>
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[[1nhz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NHZ OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nh/1nhz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nhz ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Glucocorticoid receptor|Glucocorticoid receptor]]
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*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012686538</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ahola, H.]]
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[[Category: Large Structures]]
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[[Category: Alarcon, M.]]
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[[Category: Ahola H]]
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[[Category: Calles, K.]]
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[[Category: Alarcon M]]
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[[Category: Carlquist, M.]]
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[[Category: Calles K]]
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[[Category: Carlstedt-Duke, J.]]
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[[Category: Carlquist M]]
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[[Category: Engstrom, O.]]
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[[Category: Carlstedt-Duke J]]
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[[Category: Farnegardh, M.]]
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[[Category: Engstrom O]]
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[[Category: Greer, J.]]
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[[Category: Farnegardh M]]
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[[Category: Gustafsson, J A.]]
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[[Category: Greer J]]
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[[Category: Harlan, J.]]
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[[Category: Gustafsson J-A]]
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[[Category: Jakob, C.]]
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[[Category: Harlan J]]
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[[Category: Kauppi, B.]]
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[[Category: Jakob C]]
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[[Category: Muchmore, S.]]
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[[Category: Kauppi B]]
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[[Category: Ohman, L.]]
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[[Category: Muchmore S]]
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[[Category: Ramqvist, A K.]]
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[[Category: Ohman L]]
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[[Category: Thorell, S.]]
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[[Category: Ramqvist A-K]]
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[[Category: Yang, J.]]
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[[Category: Thorell S]]
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[[Category: Anti parallel alpha helix sandwich]]
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[[Category: Yang J]]
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[[Category: Hormone receptor]]
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[[Category: Protien-ligand complex]]
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Current revision

Crystal Structure of the Antagonist Form of Glucocorticoid Receptor

PDB ID 1nhz

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