3rau
From Proteopedia
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| - | [[Image:3rau.png|left|200px]] | ||
| - | + | ==Crystal structure of the HD-PTP Bro1 domain== | |
| - | + | <StructureSection load='3rau' size='340' side='right'caption='[[3rau]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rau]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rau OCA], [https://pdbe.org/3rau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rau RCSB], [https://www.ebi.ac.uk/pdbsum/3rau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rau ProSAT]</span></td></tr> |
| - | [[3rau]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTN23_HUMAN PTN23_HUMAN] Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.<ref>PMID:18434552</ref> <ref>PMID:20393563</ref> <ref>PMID:21757351</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Tyrosine phosphatase|Tyrosine phosphatase]] | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Jiang | + | [[Category: Jiang JS]] |
| - | [[Category: Mu | + | [[Category: Mu RL]] |
| - | [[Category: Smith | + | [[Category: Smith P]] |
| - | [[Category: Snyder | + | [[Category: Snyder G]] |
| - | [[Category: Xiao | + | [[Category: Xiao T]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the HD-PTP Bro1 domain
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Categories: Homo sapiens | Large Structures | Jiang JS | Mu RL | Smith P | Snyder G | Xiao T
