2aze
From Proteopedia
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| - | [[Image:2aze.png|left|200px]] | ||
| - | + | ==Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer== | |
| - | + | <StructureSection load='2aze' size='340' side='right'caption='[[2aze]], [[Resolution|resolution]] 2.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2aze]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aze OCA], [https://pdbe.org/2aze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aze RCSB], [https://www.ebi.ac.uk/pdbsum/2aze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aze ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2aze]] is a 3 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/TFDP1_HUMAN TFDP1_HUMAN] Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).<ref>PMID:20176812</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/az/2aze_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aze ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Retinoblastoma protein|Retinoblastoma protein]] | *[[Retinoblastoma protein|Retinoblastoma protein]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Gall AL]] |
| - | [[Category: | + | [[Category: Pavletich NP]] |
| - | [[Category: | + | [[Category: Rubin SM]] |
| - | [[Category: | + | [[Category: Zheng N]] |
| - | + | ||
| - | + | ||
Current revision
Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
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