3dih

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[[Image:3dih.png|left|200px]]
 
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{{STRUCTURE_3dih| PDB=3dih | SCENE= }}
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==Crystal structure of ammodytin L==
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<StructureSection load='3dih' size='340' side='right'caption='[[3dih]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Crystal structure of ammodytin L===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vipera_ammodytes_ammodytes Vipera ammodytes ammodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DIH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dih OCA], [https://pdbe.org/3dih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dih RCSB], [https://www.ebi.ac.uk/pdbsum/3dih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dih ProSAT]</span></td></tr>
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[[3dih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vipera_ammodytes_ammodytes Vipera ammodytes ammodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DIH OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2HL_VIPAA PA2HL_VIPAA] Snake venom phospholipase A2 homolog that is very active in inducing myonecrosis in vivo and shows a potent calcium-independent membrane-damaging activity in vitro, most probably by binding and incorporating in the membrane. Also acts as a presynaptic neurotoxin.<ref>PMID:10653156</ref> <ref>PMID:11005629</ref> <ref>PMID:1765075</ref> <ref>PMID:17927217</ref> <ref>PMID:7662700</ref> <ref>PMID:8835336</ref> <ref>PMID:8973554</ref> <ref>PMID:9514950</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/3dih_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dih ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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*[[Phospholipase A2 homolog|Phospholipase A2 homolog]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vipera ammodytes ammodytes]]
[[Category: Vipera ammodytes ammodytes]]
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[[Category: Guncar, G.]]
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[[Category: Guncar G]]
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[[Category: Krizaj, I.]]
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[[Category: Krizaj I]]
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[[Category: Turk, D.]]
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[[Category: Turk D]]
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[[Category: Myotoxin]]
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[[Category: Phospholipase a2 fold]]
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[[Category: Secreted]]
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[[Category: Toxin]]
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Current revision

Crystal structure of ammodytin L

PDB ID 3dih

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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