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1tow
From Proteopedia
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| - | [[Image:1tow.png|left|200px]] | ||
| - | + | ==Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand== | |
| - | + | <StructureSection load='1tow' size='340' side='right'caption='[[1tow]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1tow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TOW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC+ACID'>CRZ</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tow OCA], [https://pdbe.org/1tow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tow RCSB], [https://www.ebi.ac.uk/pdbsum/1tow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tow ProSAT]</span></td></tr> |
| - | [[1tow]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/to/1tow_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tow ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Fatty acid-binding protein|Fatty acid-binding protein]] | + | *[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Axen | + | [[Category: Large Structures]] |
| - | [[Category: Barf | + | [[Category: Axen E]] |
| - | [[Category: Haile | + | [[Category: Barf T]] |
| - | [[Category: Lehmann | + | [[Category: Haile S]] |
| - | [[Category: Lundback | + | [[Category: Lehmann F]] |
| - | [[Category: Medina | + | [[Category: Lundback T]] |
| - | [[Category: Rondahl | + | [[Category: Medina C]] |
| - | [[Category: Svensson | + | [[Category: Rondahl L]] |
| - | [[Category: Uppenberg | + | [[Category: Svensson S]] |
| - | + | [[Category: Uppenberg J]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand
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Categories: Homo sapiens | Large Structures | Axen E | Barf T | Haile S | Lehmann F | Lundback T | Medina C | Rondahl L | Svensson S | Uppenberg J
