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1a59
From Proteopedia
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| - | [[Image:1a59.png|left|200px]] | ||
| - | + | ==COLD-ACTIVE CITRATE SYNTHASE== | |
| - | + | <StructureSection load='1a59' size='340' side='right'caption='[[1a59]], [[Resolution|resolution]] 2.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1a59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Antarctic_bacterium_DS2-3R Antarctic bacterium DS2-3R]. The September 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citrate Synthase'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_9 10.2210/rcsb_pdb/mom_2007_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A59 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a59 OCA], [https://pdbe.org/1a59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a59 RCSB], [https://www.ebi.ac.uk/pdbsum/1a59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a59 ProSAT]</span></td></tr> |
| - | [[1a59]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRPC_ABDS2 PRPC_ABDS2] Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity.<ref>PMID:9310359</ref> <ref>PMID:9579066</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/1a59_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a59 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Citrate Synthase|Citrate Synthase]] | + | *[[Citrate Synthase 3D structures|Citrate Synthase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: Antarctic bacterium | + | </StructureSection> |
| + | [[Category: Antarctic bacterium DS2-3R]] | ||
[[Category: Citrate Synthase]] | [[Category: Citrate Synthase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Danson | + | [[Category: Danson MJ]] |
| - | [[Category: Gerike | + | [[Category: Gerike U]] |
| - | [[Category: Hough | + | [[Category: Hough DW]] |
| - | [[Category: Russell | + | [[Category: Russell RJM]] |
| - | [[Category: Taylor | + | [[Category: Taylor GL]] |
| - | + | ||
Current revision
COLD-ACTIVE CITRATE SYNTHASE
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