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3eij

From Proteopedia

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[[Image:3eij.png|left|200px]]
 
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{{STRUCTURE_3eij| PDB=3eij | SCENE= }}
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==Crystal structure of Pdcd4==
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<StructureSection load='3eij' size='340' side='right'caption='[[3eij]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Crystal structure of Pdcd4===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3eij]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EIJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19153607}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eij OCA], [https://pdbe.org/3eij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eij RCSB], [https://www.ebi.ac.uk/pdbsum/3eij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eij ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3eij]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIJ OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/3eij_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eij ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cell death protein|Cell death protein]]
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019153607</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Loh, P G.]]
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[[Category: Large Structures]]
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[[Category: Anti-oncogene]]
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[[Category: Loh PG]]
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[[Category: Antitumor protein]]
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[[Category: Apoptosis]]
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[[Category: Cell cycle]]
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[[Category: Heat motif]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein]]
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[[Category: Rna-binding]]
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[[Category: Translation]]
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Current revision

Crystal structure of Pdcd4

PDB ID 3eij

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