3ajn

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[[Image:3ajn.png|left|200px]]
 
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{{STRUCTURE_3ajn| PDB=3ajn | SCENE= }}
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==Structural basis of glycine amide on suppression of protein aggregation by high resolution X-ray analysis==
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<StructureSection load='3ajn' size='340' side='right'caption='[[3ajn]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ajn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zxs 2zxs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AJN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GM1:AMINOMETHYLAMIDE'>GM1</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ajn OCA], [https://pdbe.org/3ajn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ajn RCSB], [https://www.ebi.ac.uk/pdbsum/3ajn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ajn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glycine amide (GlyAd), a typically amidated amino acid, is a versatile additive that suppresses protein aggregation during refolding, heat treatment, and crystallization. In spite of its effectiveness, the exact mechanism by which GlyAd suppresses protein aggregation remains to be elucidated. Here, we show the crystal structure of the GlyAd-lysozyme complex by high resolution X-ray crystallographic analysis at a 1.05A resolution. GlyAd bound to the lysozyme surface near aromatic residues and decreased the amount of bound waters and increased the mobility of protein. Arg and GlyAd molecules are different in binding sites and patterns from glycerol and related compounds, indicating that decreasing hydrophobic patches might be involved in suppression of protein aggregation.
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===Structural basis of glycine amide on suppression of protein aggregation by high resolution X-ray analysis===
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Glycine amide shielding on the aromatic surfaces of lysozyme: Implication for suppression of protein aggregation.,Ito L, Shiraki K, Makino M, Hasegawa K, Kumasaka T FEBS Lett. 2011 Feb 4;585(3):555-60. Epub 2011 Jan 14. PMID:21237160<ref>PMID:21237160</ref>
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{{ABSTRACT_PUBMED_21237160}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3ajn" style="background-color:#fffaf0;"></div>
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[[3ajn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zxs 2zxs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJN OCA].
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==See Also==
==See Also==
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*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021237160</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Hasegawa, K.]]
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[[Category: Hasegawa K]]
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[[Category: Ito, L.]]
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[[Category: Ito L]]
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[[Category: Kumasaka, T.]]
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[[Category: Kumasaka T]]
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[[Category: Shiraki, K.]]
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[[Category: Shiraki K]]
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[[Category: Glycine amide]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Lysozyme]]
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Current revision

Structural basis of glycine amide on suppression of protein aggregation by high resolution X-ray analysis

PDB ID 3ajn

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