1zye

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[[Image:1zye.png|left|200px]]
 
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{{STRUCTURE_1zye| PDB=1zye | SCENE= }}
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==Crystal structure analysis of Bovine Mitochondrial Peroxiredoxin III==
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<StructureSection load='1zye' size='340' side='right'caption='[[1zye]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zye]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zye OCA], [https://pdbe.org/1zye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zye RCSB], [https://www.ebi.ac.uk/pdbsum/1zye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zye ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRDX3_BOVIN PRDX3_BOVIN] Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zye_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zye ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A crystal structure is reported for the C168S mutant of a typical 2-Cys peroxiredoxin III (Prx III) from bovine mitochondria at a resolution of 3.3 A. Prx III is present as a two-ring catenane comprising two interlocking dodecameric toroids that are assembled from basic dimeric units. Each ring has an external diameter of 150 A and encompasses a central cavity that is 70 A in width. The concatenated dodecamers are inclined at an angle of 55 degrees, which provides a large contact surface between the rings. Dimer-dimer contacts involved in toroid formation are hydrophobic in nature, whereas the 12 areas of contact between interlocked rings arise from polar interactions. These two major modes of subunit interaction provide important insights into possible mechanisms of catenane formation.
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===Crystal strucutre analysis of Bovine Mitochondrial Peroxiredoxin III===
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Bovine mitochondrial peroxiredoxin III forms a two-ring catenane.,Cao Z, Roszak AW, Gourlay LJ, Lindsay JG, Isaacs NW Structure. 2005 Nov;13(11):1661-4. PMID:16271889<ref>PMID:16271889</ref>
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{{ABSTRACT_PUBMED_16271889}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1zye" style="background-color:#fffaf0;"></div>
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[[1zye]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYE OCA].
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==See Also==
==See Also==
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*[[Peroxiredoxin|Peroxiredoxin]]
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016271889</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Peroxiredoxin]]
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[[Category: Large Structures]]
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[[Category: Cao, Z.]]
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[[Category: Cao Z]]
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[[Category: Gourlay, L J.]]
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[[Category: Gourlay LJ]]
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[[Category: Isaacs, N W.]]
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[[Category: Isaacs NW]]
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[[Category: Lindsay, J G.]]
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[[Category: Lindsay JG]]
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[[Category: Roszak, A W.]]
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[[Category: Roszak AW]]
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[[Category: Catenane]]
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[[Category: Dodecamer]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxiredoxin]]
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Current revision

Crystal structure analysis of Bovine Mitochondrial Peroxiredoxin III

PDB ID 1zye

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