3pgw

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[[Image:3pgw.png|left|200px]]
 
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{{STRUCTURE_3pgw| PDB=3pgw | SCENE= }}
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==Crystal structure of human U1 snRNP==
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<StructureSection load='3pgw' size='340' side='right'caption='[[3pgw]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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===Crystal structure of human U1 snRNP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pgw]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21113136}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgw OCA], [https://pdbe.org/3pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgw RCSB], [https://www.ebi.ac.uk/pdbsum/3pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgw ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3pgw]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGW OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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*[[Sm-like protein 3D structures|Sm-like protein 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:021113136</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kastner, B.]]
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[[Category: Large Structures]]
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[[Category: Luehrmann, R.]]
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[[Category: Kastner B]]
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[[Category: Trowitzsch, S.]]
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[[Category: Luehrmann R]]
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[[Category: Wahl, M C.]]
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[[Category: Trowitzsch S]]
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[[Category: Weber, G.]]
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[[Category: Wahl MC]]
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[[Category: Mrna]]
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[[Category: Weber G]]
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[[Category: Protein-rna complex]]
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[[Category: Rrm]]
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[[Category: Sm core]]
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[[Category: Sm fold]]
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[[Category: Snrnp]]
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[[Category: Splicing]]
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[[Category: Splicing factor]]
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[[Category: Splicing-dna-rna complex]]
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[[Category: U1 snrna]]
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Current revision

Crystal structure of human U1 snRNP

PDB ID 3pgw

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OCA

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