2dx5

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[[Image:2dx5.png|left|200px]]
 
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{{STRUCTURE_2dx5| PDB=2dx5 | SCENE= }}
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==The complex structure between the mouse EAP45-GLUE domain and ubiquitin==
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<StructureSection load='2dx5' size='340' side='right'caption='[[2dx5]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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===The complex structure between the mouse EAP45-GLUE domain and ubiquitin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DX5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17057714}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx5 OCA], [https://pdbe.org/2dx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dx5 RCSB], [https://www.ebi.ac.uk/pdbsum/2dx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dx5 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2dx5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX5 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/VPS36_MOUSE VPS36_MOUSE] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dx5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dx5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ubiquitin|Ubiquitin]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017057714</ref><ref group="xtra">PMID:019773779</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hirano, S.]]
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[[Category: Hirano S]]
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[[Category: Kato, R.]]
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[[Category: Kato R]]
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[[Category: Kawasaki, M.]]
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[[Category: Kawasaki M]]
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[[Category: Slagsvold, T.]]
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[[Category: Slagsvold T]]
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[[Category: Stenmark, H.]]
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[[Category: Stenmark H]]
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[[Category: Suzuki, N.]]
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[[Category: Suzuki N]]
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[[Category: Trambaiolo, D.]]
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[[Category: Trambaiolo D]]
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[[Category: Wakatsuki, S.]]
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[[Category: Wakatsuki S]]
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[[Category: Protein transport-signaling protein complex]]
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[[Category: Protein-protein complex]]
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[[Category: Ubiquitin]]
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Current revision

The complex structure between the mouse EAP45-GLUE domain and ubiquitin

PDB ID 2dx5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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