3iyd

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[[Image:3iyd.png|left|200px]]
 
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{{STRUCTURE_3iyd| PDB=3iyd | SCENE= }}
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==Three-dimensional EM structure of an intact activator-dependent transcription initiation complex==
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<SX load='3iyd' size='340' side='right' viewer='molstar' caption='[[3iyd]], [[Resolution|resolution]] 19.80&Aring;' scene=''>
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===Three-dimensional EM structure of an intact activator-dependent transcription initiation complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3iyd]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYD FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19903881}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 19.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyd OCA], [https://pdbe.org/3iyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iyd RCSB], [https://www.ebi.ac.uk/pdbsum/3iyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyd ProSAT]</span></td></tr>
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[[3iyd]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYD OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/3iyd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iyd ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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==Reference==
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
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<ref group="xtra">PMID:019903881</ref><references group="xtra"/>
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__TOC__
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[[Category: DNA-directed RNA polymerase]]
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</SX>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli k-12]]
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[[Category: Large Structures]]
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[[Category: Arnold, E.]]
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[[Category: Arnold E]]
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[[Category: Berman, H.]]
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[[Category: Berman H]]
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[[Category: Ebright, R H.]]
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[[Category: Ebright RH]]
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[[Category: Hudson, B P.]]
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[[Category: Hudson BP]]
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[[Category: Kim, Y.]]
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[[Category: Kim Y]]
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[[Category: Lara, S.]]
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[[Category: Lara S]]
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[[Category: Lawson, C L.]]
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[[Category: Lawson CL]]
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[[Category: Quispe, J.]]
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[[Category: Quispe J]]
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[[Category: Activator]]
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[[Category: Camp]]
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[[Category: Camp-binding]]
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[[Category: Camp-dependent]]
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[[Category: Cap]]
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[[Category: Class i]]
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[[Category: Crp]]
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[[Category: Dna]]
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[[Category: Dna-binding]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: Holoenzyme]]
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[[Category: Initiation]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Open complex]]
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[[Category: Prokaryotic]]
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[[Category: Rna polymerase]]
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[[Category: Sigma factor]]
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[[Category: Sigma70]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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[[Category: Transferase]]
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Current revision

Three-dimensional EM structure of an intact activator-dependent transcription initiation complex

3iyd, resolution 19.80Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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