1lvc

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[[Image:1lvc.png|left|200px]]
 
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{{STRUCTURE_1lvc| PDB=1lvc | SCENE= }}
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==Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP==
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<StructureSection load='1lvc' size='340' side='right'caption='[[1lvc]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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===Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lvc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LVC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12485993}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOT:3ANTHRANILOYL-2-DEOXY-ADENOSINE-5-TRIPHOSPHATE'>DOT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lvc OCA], [https://pdbe.org/1lvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lvc RCSB], [https://www.ebi.ac.uk/pdbsum/1lvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lvc ProSAT]</span></td></tr>
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[[1lvc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lv/1lvc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lvc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Adenylyl cyclase|Adenylyl cyclase]]
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*[[Anthrax edema factor 3D structures|Anthrax edema factor 3D structures]]
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*[[Anthrax edema factor|Anthrax edema factor]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Calmodulin|Calmodulin]]
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012485993</ref><references group="xtra"/>
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[[Category: Adenylate cyclase]]
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Beckingham, K.]]
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[[Category: Large Structures]]
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[[Category: Bergson, P.]]
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[[Category: Beckingham K]]
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[[Category: Chen, A.]]
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[[Category: Bergson P]]
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[[Category: Grabarek, Z.]]
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[[Category: Chen A]]
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[[Category: Lee, Y S.]]
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[[Category: Grabarek Z]]
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[[Category: Lu, D.]]
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[[Category: Lee Y-S]]
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[[Category: Mrksich, M.]]
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[[Category: Lu D]]
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[[Category: Shen, Y.]]
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[[Category: Mrksich M]]
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[[Category: Soelaiman, S.]]
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[[Category: Shen Y]]
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[[Category: Tang, W J.]]
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[[Category: Soelaiman S]]
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[[Category: Helical domain]]
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[[Category: Tang W-J]]
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[[Category: Lyase]]
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[[Category: Protein-protein complex]]
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Current revision

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP

PDB ID 1lvc

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